[Immunological changes in patients with colorectal cancer]

Sera, duodenal liquid and biopsy materials of small intestine and of mesenteric lymph nodes were collected from 22 patients with colorectal cancer (intestinal lymphoma and adenocarcinoma) and 10 control patients with gastric ulcer were found in all of patients with cancer. The increasing of B type lymphocytes and decreasing of T cells were detected in biopsy materials and high level IgA was found in the sera and duodenal liquid of these patients. The immunological alterations were not seen in control patients with gastric ulcer. These findings suggest that there is a role of cellular and humoral immunological alterations in the development of colorectal cancer.