Related Experiment Videos
Evidence for relationships between antiperinuclear and IgG rheumatoid factor
Rheumatology International
|January 1, 1984
Summary
Antiperinuclear factor (APF) and IgG-rheumatoid factor (IgG-RF) are prevalent in autoimmune diseases like rheumatoid arthritis and Sjögren
Area of Science:
- Immunology
- Rheumatology
Background:
- Antiperinuclear factor (APF) and IgG-rheumatoid factor (IgG-RF) are autoantibodies.
- Both APF and IgG-RF are detected in various autoimmune conditions.
Purpose of the Study:
- To investigate the relationship between APF and IgG-RF.
- To determine if IgG-RF possesses APF activity.
Main Methods:
- Statistical analysis of APF and IgG-RF prevalence in patient cohorts.
- Experimental purification and testing of IgG-RF for APF activity.
Main Results:
- APF detected in 64% of rheumatoid arthritis, 36% of psoriasis, and 31% of Sjögren's syndrome cases.
- IgG-RF detected in 48% of rheumatoid arthritis, 50% of psoriasis, and 45% of Sjögren's syndrome cases.
- Purified IgG-RF demonstrated APF activity.
Conclusions:
- A strong association exists between APF and IgG-RF.
- IgG-RF may contribute to APF activity, suggesting a shared pathogenic mechanism in autoimmune diseases.