Synthesis and CNS-depressant profile of 3,4,5-trimethoxybenzoyl analogues

A series of 3,4,5-trimethoxybenzoyl analogues with varying electronic and stereochemical characteristics has has been synthesized. Many of these compounds (4, 5, 9, 12, 15) showed appreciable potentiation of pentobarbitone-induced hyposis. Several analogues (1, 5, 6, 11, 12, 15) exhibited marked reduction of Spontaneous motor activity (SMA).