Use of a fractional factorial design to evaluate granulations prepared in a fluidized bed

Sulfadiazine granules were prepared in a fluidized bed granulator. The granulation conditions such as binder concentration, velocity and temperature of fluidizing air, pressure of compressed air and binder solution flow rate were studied at two levels, low and high. By applying fractional factorial design the effect of these granulation conditions as well as the interaction among them, on the granules physical characters were assessed.