Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epinephrine mediated increases in plasma cholesterol.

J E Dimsdale, J A Herd, L H Hartley

    Psychosomatic Medicine
    |June 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of stress on heart rate complexity--a comparison between short-term and chronic stress.

    Biological psychology·2008
    Same author

    The attenuating effect of personal mastery on the relations between stress and Alzheimer caregiver health: a five-year longitudinal analysis.

    Aging & mental health·2007
    Same author

    Pain in the aftermath of trauma is a risk factor for post-traumatic stress disorder.

    Psychological medicine·2007
    Same author

    Severe irritability associated with statin cholesterol-lowering drugs.

    QJM : monthly journal of the Association of Physicians·2004
    Same author

    Taking fatigue seriously: I. Variations in fatigue sampled repeatedly in healthy controls.

    Journal of medical engineering & technology·2003
    Same author

    Association between polysomnographic sleep measures and health-related quality of life in obstructive sleep apnea.

    Journal of sleep research·2002

    Physiological elevations in plasma epinephrine, a stress hormone, significantly increased plasma cholesterol levels in cynomolgus monkeys after only two weeks. This suggests a direct link between short-term stress responses and lipid metabolism.

    Area of Science:

    • Endocrinology
    • Cardiovascular Science
    • Metabolic Research

    Background:

    • Plasma cholesterol is a key indicator of cardiovascular health.
    • Epinephrine (adrenaline) is a hormone released during stress.
    • The relationship between acute epinephrine surges and cholesterol metabolism requires further elucidation.

    Purpose of the Study:

    • To investigate the impact of physiologically elevated plasma epinephrine levels on plasma cholesterol concentrations.
    • To determine if short-term exposure to increased epinephrine affects lipid profiles.

    Main Methods:

    • Ten cynomolgus monkeys were subjected to increased plasma epinephrine levels.
    • Epinephrine levels were elevated for 6 hours daily, 5 days a week.
    • Plasma cholesterol levels were monitored over a two-week period.

    Related Experiment Videos

    Main Results:

    • A statistically significant increase in average plasma cholesterol levels was observed.
    • Cholesterol levels rose by approximately 15 mg% (p < 0.01) after two weeks.
    • The results indicate a direct correlation between epinephrine elevation and increased cholesterol.

    Conclusions:

    • Physiological elevations in plasma epinephrine can acutely increase plasma cholesterol levels.
    • This finding highlights a potential mechanism linking stress and adverse lipid changes.
    • Further research is warranted to explore the long-term cardiovascular implications.