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[Hemato-encephalic barriers. Morphologic data].

J Poirier, J Fleury, R Ghérardi

    La Revue De Medecine Interne
    |June 1, 1983
    PubMed
    Summary
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    The study reveals distinct blood-brain and blood-cerebrospinal fluid barriers, with the brain-parenchyma interface lacking barrier function. Spinal cord capillaries possess unique perivascular spaces with unknown significance.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Anatomy

    Context:

    • The cranio-spinal cavity contains three compartments: blood, cerebrospinal fluid (CSF), and nervous parenchyma.
    • Three distinct barriers exist: Blood-Cerebrospinal Fluid (BCSFB), Blood-Brain Barrier (BBB), and Cerebrospinal Fluid-Brain (CSFB).
    • Morphological studies utilized exogenous tracers (horseradish peroxidase, cytochrome C, ferritin) and endogenous tracers (autologous antiperoxidase immunoglobulins).

    Purpose:

    • To investigate the morphological characteristics of the barriers within the cranio-spinal cavity.
    • To differentiate the barrier functions at the blood-brain, blood-CSF, and brain-CSF interfaces.
    • To examine tracer diffusion across these barriers using electron microscopy.

    Summary:

    • The Blood-Brain Barrier (BBB) is confirmed by tracer studies, located at brain capillary endothelium with tight junctions and few vesicles.

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  • The Blood-Cerebrospinal Fluid Barrier (BCSFB) is identified at the choroid plexus (epithelial tight junctions) and leptomeningeal vessels (endothelial tight junctions).
  • The parenchymal-CSF interface is not a barrier, allowing free tracer diffusion, unlike circumventricular organs (except subcommissural organ capillaries) and spinal cord capillaries with perivascular spaces.

    • Impact:

    • Provides detailed morphological evidence differentiating key neurovascular barriers.
    • Clarifies the absence of a barrier at the brain-parenchyma interface, impacting understanding of substance exchange.
    • Highlights unique features of spinal cord capillaries, suggesting potential regional differences in CNS physiology and opening avenues for future research.