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Related Experiment Videos

[Bladder sphincter disorders in Parkinson's disease].

B Aranda, M Perrigot, L Mazières

    Revue Neurologique
    |January 1, 1983
    PubMed
    Summary

    Urinary dysfunction, including urgency and incontinence, is common in Parkinson's disease (PD) and often presents early. Urodynamic findings suggest detrusor muscle dysfunction is the primary cause, responding variably to treatments.

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    Recurrent inhibition of the bladder C fibre reflex in the cat and its response to naloxone.

    The Journal of physiology·2006

    Area of Science:

    • Neurology
    • Urology
    • Urodynamics

    Context:

    • Parkinson's disease (PD) frequently involves urinary dysfunction.
    • These symptoms can be the initial presentation of PD.
    • Lack of recognition in routine exams leads to varied incidence reports.

    Purpose:

    • To investigate the clinical and urodynamic characteristics of urinary bladder sphincter disorders in Parkinson's disease patients.
    • To determine the underlying cause of these micturition disturbances.
    • To explore potential therapeutic interventions.

    Summary:

    • 63 Parkinson's disease patients with urinary disorders underwent clinical and urodynamic evaluation.
    • Findings revealed detrusor hyperactivity (60%) and hypoactivity (35%), indicating central neurologic origin and detrusor muscle dysfunction.
    • Urgency and incontinence were frequent complaints, sometimes being the earliest PD symptom.

    Impact:

    • Highlights the significant role of detrusor muscle dysfunction in PD-related urinary issues.
    • Suggests L-Dopa may influence detrusor hypoactivity centrally.
    • Indicates anticholinergic agents are effective for hypoactivity, though improving it remains challenging.

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