[Kidney load in spleen irradiation in lymphogranulomatosis patients]

Within the period of 1972 to 1982, 35 patients suffering from lymphogranulomatosis had to be treated by para-aortal pendulum therapy and irradiation of the spleen or spleen pedicle. Some of these patients received an additional polychemotherapy. All of these 35 patients were regularly checked-up by clinical and laboratory examinations in oncologic departments. There were no signs of radiogenic lesions of the kidney. In spite of this, the urines of these patients were examined by discelectrophoresis. Eight patients had a pathologic protein spectrum which was a symptom of other diseases in two cases and did not appear again in four cases, when control examinations were performed. One patient refused the control examination, but this one had no pathologic modifications in abdominal CT. Just one female patient showed in three control examinations protein spectra resembling to those of a proliferating glomerular lesion and a tubular lesion. All the other parameters, including a functional scintigraphy of the kidney, were normal. The patient felt well and had no clinical signs of disease. A functional damage of the kidney after irradiation of the spleen cannot be identified by current clinical and laboratory methods.