[Transmural gastric potential difference (PD) and intragastric diurnal pH profile with proglumide]

The presented double-blind cross-over-study evaluates the effect of proglumide on gastric potential difference (PD) and the PD-response to irritation of the gastric mucosal barrier by acetylsalicylic acid (ASA). Both, in an acute and a 6-day trial, no protective effect against the mucosal barrier breaker ASA was noticed. Furthermore, the 6-day administration of proglumide neither changed the 23-hour gastric pH-profiles nor the postprandial course of intragastric pH. The findings are shown in contrast to the action of cimetidine. The study shows, that proglumide neither reduces the aggressive factor acidity nor works protective at the gastric mucosal barrier.