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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Lowering of blood pressure after stroke
Insights
Stroke can significantly lower blood pressure in hypertensive patients. This study found that 64% of stroke patients experienced reduced blood pressure by the second hospital day, suggesting a stroke-induced hypotensive effect.
Area of Science:
- Neurology
- Cardiology
- Clinical Medicine
Background:
- Hypertension is a significant risk factor for stroke.
- The effect of stroke on blood pressure is not fully understood.
- Previous studies have not extensively documented the spontaneous reduction of blood pressure following a stroke.
Purpose of the Study:
- To determine the incidence of blood pressure reduction in patients following a stroke.
- To investigate the potential blood pressure-lowering effect of stroke itself.
Main Methods:
- Retrospective review of 100 stroke patients' medical records.
- Blood pressure measurements recorded on admission, second hospital day, and discharge.
- Hypertension defined as systolic blood pressure >160 mmHg and diastolic blood pressure >90 mmHg.
Main Results:
- Of 100 stroke patients, 47 were identified as hypertensive.
- Of the hypertensive patients, 13% showed reduced blood pressure on admission.
- By the second hospital day, 64% of hypertensive stroke patients became normotensive.
Conclusions:
- Stroke appears to have a blood pressure-lowering effect in hypertensive individuals.
- A significant percentage of hypertensive patients experience normotension following a stroke.
- Further research is warranted to elucidate the mechanisms behind stroke-induced blood pressure reduction.
Abstract:
This study attempted to determine the occurrence rate of blood pressure reduction after stroke by reviewing 100 patients with stroke diagnosed by clinical and laboratory studies. Retrospectively, blood pressures were noted on admission, 2nd hospital day and on discharge. Hypertension was defined as readings over 160 mmHg systolic and 90 mmHg diastolic. Pre-stroke and stroke blood pressures along with pressures during hospitalization for other diseases were also studied, totaling 252 admissions. Patients with congestive heart failure, myocardial infarction, coma and those who died were not counted. Of the 100 stroke patients, 47 hypertensives, consisting of 28 females and 19 males with a mean age of 69 years, were used. At the time of their stroke, 6 hypertensive patients were normotensive, 31 were normotensive from the 2nd hospital day and an additional 7 were normotensive on the day of discharge. One patient had labile blood pressures and 3 patients remained hypertensive. This study documents stroke as having a blood pressure lowering effect occurring in 13% of stroke patients on admission and in 64% by the 2nd hospital day. These observations in the hypertensive patient, rendered normotensive with stroke, suggests stroke has its own blood pressure lowering effect.
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