Pure red blood cell aplasia complicating chronic lymphatic leukemia

While the occurrence of autoimmune disorders such as hemolytic anemia and thrombocytopenia in chronic lymphatic leukemia (CLL) is well recognized, pure red blood cell aplasia (PRCA) complicating CLL is uncommon and intriguing. This is a report of the clinical course of a patient with B cell CLL who developed PRCA unresponsive to immunosuppressive therapy responsive to subsequent treatment with oxymethalone resulting in complete remission of PRCA.