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Related Experiment Videos

Upper thoracic sympathetic neuron responses to input from urinary bladder afferents.

R Schondorf, W Laskey, C Polosa

    The American Journal of Physiology
    |September 1, 1983
    PubMed
    Summary

    This study reveals how urinary bladder signals reach sympathetic preganglionic neurons (SPNs) through spinal cord circuits. Both central nervous system (CNS)-intact and spinal cats show bladder afferent input influences SPNs.

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    Area of Science:

    • Neuroscience
    • Autonomic Nervous System Research
    • Visceral Afferent Signaling

    Background:

    • The neural pathways controlling bladder function and their integration with the sympathetic nervous system are complex.
    • Understanding the intersegmental transmission of bladder afferent information to sympathetic preganglionic neurons (SPNs) is crucial for autonomic regulation.

    Purpose of the Study:

    • To investigate the neural circuitry mediating the transmission of urinary bladder afferent signals to SPNs.
    • To determine the involvement of both spinal and supraspinal pathways in this process.

    Main Methods:

    • Recording electrical activity of SPNs in cats under different preparations: CNS-intact, midcollicular-decerebrate, and acute spinal.
    • Stimulating pelvic and hypogastric nerves containing bladder afferents.

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  • Inducing bladder distension and observing SPN responses.
  • Performing pelvic nerve section to assess the role of specific afferent pathways.

    • Main Results:

    • Tonically active SPNs exhibited excitation or inhibition in response to pelvic/hypogastric nerve stimulation and bladder distension.
    • SPN responses to bladder distension were eliminated after pelvic nerve section.
    • Comparison between CNS-intact and spinal preparations indicated the involvement of both propriospinal and supraspinal circuits.

    Conclusions:

    • The study elucidates the neural organization for intersegmental bladder afferent input to SPNs.
    • Both propriospinal and supraspinal pathways contribute to the processing of bladder information by SPNs.
    • Findings provide insights into the central neural control of bladder function and sympathetic outflow.