[Non-extractible residues of aryl-14C-albendazole in sheep]

The location of the intractable residues of 14C-ring labelled-albendazole has been investigated in the sheep. Numerous biochemical compounds have been isolated: pulmonary CO2, blood dextrose, glycogen, triglycerides, cholesterol, hemoglobin, plasmatic, cytosolic and microsomal proteins, nucleic acids . . . No incorporation into intermediary metabolisms has been put into evidence. On the contrary, a significant covalently bound radioactivity has been observed on hepatic and plasmatic proteins. No covalent binding to hepatic DNA seems to be produced.