Related Experiment Video

Updated: Sep 9, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Successful thrombolytic therapy for acute and chronic occlusion of polytef vascular grafts

C J Bisig, M D Kerstein

    Archives of Surgery (Chicago, Ill. : 1960)
    |October 1, 1983
    PubMed

    Insights

    Thrombolytic therapy successfully restored blood flow in occluded polytetrafluoroethylene (PTFE) arterial bypass grafts without surgery. This treatment offers a promising, less invasive option for managing thrombosed vascular grafts.

    Area of Science:

    • Vascular Surgery
    • Interventional Cardiology
    • Thrombosis Management

    Background:

    • Thrombolytic therapy for thrombosed arterial bypass grafts is understudied.
    • Polytetrafluoroethylene (PTFE) grafts are common in vascular reconstructions.
    • Graft thrombosis necessitates timely intervention to restore perfusion.

    Observation:

    • Two patients with occluded PTFE grafts (13 days and 3 months) underwent thrombolysis.
    • No surgical intervention was required for graft recanalization.
    • Both grafts remained patent nine months post-thrombolysis.

    Findings:

    • Successful thrombolysis was achieved in both occluded PTFE arterial bypass grafts.
    • Thrombus within PTFE grafts demonstrated susceptibility to lysis.
    • Continued graft patency was observed long-term after thrombolytic treatment.

    Implications:

    • Thrombolytic therapy presents a viable, non-surgical alternative for thrombosed PTFE grafts.
    • Long-term anticoagulation may be beneficial following successful thrombolysis.
    • Thrombolysis is poised to become a more significant tool in vascular surgery.

    More Related Videos

    Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock06:30

    Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock

    Published on: May 19, 2022

    The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo06:38

    The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

    Published on: December 19, 2025

    Related Concept Videos

    Clot Retraction and Fibrinolysis01:16

    Clot Retraction and Fibrinolysis

    After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
    Peripheral Artery Disease III: Interprofessional Care01:27

    Peripheral Artery Disease III: Interprofessional Care

    Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
    Venous Thrombosis III: Interprofessional Care01:29

    Venous Thrombosis III: Interprofessional Care

    Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
    Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

    Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

    Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...