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Related Experiment Videos

Unsuspected multiple sclerosis.

J J Gilbert, M Sadler

    Archives of Neurology
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Multiple sclerosis (MS) plaques were unexpectedly discovered during autopsies in five patients with other medical conditions. These characteristic lesions were primarily small and located around the ventricles in the brain, with some also found in the thalamus and brain stem.

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    Area of Science:

    • Neurology
    • Pathology
    • Autopsy Studies

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
    • MS is typically diagnosed through clinical symptoms and MRI findings.
    • Autopsy confirmation of MS plaques in patients with confounding medical histories is rare.

    Purpose of the Study:

    • To report the incidental finding of multiple sclerosis plaques in patients undergoing autopsy for unrelated medical conditions.
    • To describe the location and characteristics of these unexpectedly discovered MS plaques.

    Main Methods:

    • Retrospective autopsy examination of five patients with pre-existing medical conditions.
    • Histopathological analysis to identify characteristic demyelinating plaques of multiple sclerosis.

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  • Detailed documentation of plaque location and size within the central nervous system.

    • Main Results:

    • Typical multiple sclerosis plaques were identified in five patients during post-mortem examination.
    • Lesions were predominantly small and located in a periventricular distribution within the frontal, temporal, and occipital lobes.
    • In two cases, plaques were also observed in the thalamus and brain stem; the cerebellum was unaffected.

    Conclusions:

    • Multiple sclerosis can present with subtle neuropathological findings detectable at autopsy, even in patients with other significant medical issues.
    • The periventricular white matter of the frontal, temporal, and occipital lobes are common sites for these incidental MS plaques.
    • These findings highlight the importance of thorough neuropathological examination for diagnosing MS, especially in complex cases.