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A systemic hemodynamic evaluation of indapamide.

G Gensini, P Esente, A Giambartolomei

    Clinical Therapeutics
    |January 1, 1983
    PubMed
    Summary
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    Indapamide effectively lowers blood pressure in hypertensive patients by reducing total peripheral resistance. This study found significant reductions in systolic and diastolic blood pressure after six weeks of treatment.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Hypertension is a prevalent cardiovascular condition requiring effective treatment.
    • Diuretics are a common class of antihypertensive medications.

    Purpose of the Study:

    • To evaluate the hemodynamic effects of indapamide in patients with mild to moderate hypertension.
    • To assess the safety and tolerability of indapamide treatment.

    Main Methods:

    • An open clinical trial involving nine patients with hypertension.
    • Hemodynamic and echocardiographic measurements were taken before and after six weeks of daily 2.5 mg indapamide dosage.
    • Analysis included blood pressure, cardiac output, and peripheral vascular resistance.

    Main Results:

    • Indapamide significantly reduced systolic blood pressure (P<0.025), diastolic blood pressure (P<0.01), mean arterial blood pressure (P<0.001), and total peripheral vascular resistance (P<0.01).

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  • Cardiac output showed a significant increase of 12% (P<0.05).
  • Heart rate and ventricular volumes remained largely unchanged, with a slight decrease in systolic wall stress index.

    • Conclusions:

    • Indapamide effectively lowers arterial blood pressure in hypertensive individuals.
    • The primary mechanism appears to be a reduction in total peripheral vascular resistance.
    • Indapamide was well-tolerated with no significant adverse effects over the six-week treatment period.