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Glycogenolysis in the fasting dog.

J J de Bruijne, P de Koster

    Comparative Biochemistry and Physiology. B, Comparative Biochemistry
    |January 1, 1983
    PubMed
    Summary

    In fasting dogs, liver glycogen depletion peaks between days two and three, occurring slower than in humans or rats. This suggests more glycerol is available for gluconeogenesis in dogs during starvation.

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    Area of Science:

    • Veterinary Medicine
    • Animal Physiology
    • Biochemistry

    Background:

    • Understanding how different species metabolize energy during fasting is crucial for comparative physiology.
    • Liver glycogen serves as a primary energy reserve, and its depletion rate indicates metabolic adaptation to starvation.

    Purpose of the Study:

    • To investigate the rate of liver glycogen depletion in dogs during prolonged fasting.
    • To compare canine glycogenolysis with that of other species like humans and rats.
    • To explore the implications for gluconeogenesis in fasting dogs.

    Main Methods:

    • Liver biopsy specimens were collected from four dogs over five consecutive days of fasting.
    • Glycogen concentrations were measured in these biopsy samples.

    Main Results:

    • Maximal depletion of liver glycogen was observed between the second and third day of fasting.
    • The rate of starvation-induced glycogenolysis in dogs was significantly slower compared to humans and rats.
    • Preliminary analysis suggests greater glycerol availability for gluconeogenesis in fasting dogs.

    Conclusions:

    • Dogs exhibit a slower rate of liver glycogen depletion during fasting compared to humans and rats.
    • The fasting dog may utilize glycerol for gluconeogenesis more extensively than other species.
    • Further research into fuel fluxes during canine starvation is warranted.

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