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Antioxidant system and ozone tolerance.

Z Nambu, E Yokoyama

    Environmental Research
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Ozone tolerance in rats develops before antioxidant system enhancement. Inhibiting tolerance with drugs did not affect antioxidant levels, suggesting tolerance is independent of this system.

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    Area of Science:

    • Environmental toxicology
    • Pulmonary toxicology
    • Biochemistry

    Background:

    • Ozone exposure can cause lung injury.
    • Ozone tolerance is a protective response to repeated ozone exposure.
    • The role of the antioxidant system in ozone tolerance is not fully understood.

    Purpose of the Study:

    • To investigate the relationship between the development of ozone tolerance and the antioxidant system in rat lungs.
    • To determine if the antioxidant system is responsible for ozone tolerance.

    Main Methods:

    • Rats were exposed to 2 ppm ozone to induce tolerance.
    • Lung nonprotein SH content and antioxidant enzyme activities (glutathione peroxidase, glutathione reductase, glucose 6-phosphate dehydrogenase) were measured.
    • Tolerance was assessed by a challenge exposure to 5.6 ppm ozone.

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  • Drug treatments (actinomycin D, colchicine) were used to suppress tolerance induction.

    • Main Results:

    • Ozone tolerance developed prior to the enhancement of the antioxidant system.
    • Drug-induced suppression of tolerance did not significantly alter antioxidant system levels.
    • Partial enhancement of the antioxidant system was observed, but it did not correlate with tolerance.

    Conclusions:

    • Ozone tolerance in rats is not directly related to the enhancement of the antioxidant system.
    • The mechanisms underlying ozone tolerance may involve pathways other than antioxidant system upregulation.