Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differential sensitivity to morphine in nervous and normal pointer dogs.

C Angel, D E McMillan, J E Newton

    European Journal of Pharmacology
    |August 5, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A formal description of the growth and composition of bones in male and female broilers.

    British poultry science·2025
    Same author

    Prostate cancer presenting as an oral swelling-A case report.

    Australian dental journal·2024
    Same author

    Patient and family perceptions of a discharge bedside board.

    PEC innovation·2023
    Same author

    On-farm net benefit of genotyping candidate female replacement cattle and sheep.

    Animal : an international journal of animal bioscience·2020
    Same author

    Can radiological examination of mandibular bone invasion accurately predict the need for mandibular resection in oral squamous cell carcinoma?

    International journal of oral and maxillofacial surgery·2018
    Same author

    Comparative efficacy of ivermectin and Nigella sativa against helminths in Aseel chickens (Gallus gallus domesticus).

    Journal of helminthology·2018
    Same journal

    Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectional αIIbβ3 signaling.

    European journal of pharmacology·2026
    Same journal

    Repurposing of alogliptin to mitigate experimentally-induced ulcerative colitis and its associated pulmonary injury in rats through regulating inflammatory, necroptotic, and ER stress pathways.

    European journal of pharmacology·2026
    Same journal

    Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

    European journal of pharmacology·2026
    Same journal

    4-Octyl itaconate attenuates renal calculi formation by inhibiting ferroptosis and oxidative stress via the Nrf2-HO-1/SLC7A11 axis.

    European journal of pharmacology·2026
    Same journal

    VER155008 rescues cognitive impairment in P301S tauopathy mice by promoting HSPA8-mediated lipophagy.

    European journal of pharmacology·2026
    Same journal

    Okanin alleviates osteoarthritis by suppressing oxidative stress and pyroptosis via Nrf2/HO-1 activation.

    European journal of pharmacology·2026
    See all related articles

    Genetically nervous dogs exhibit reduced responses to morphine, showing less change in heart rate and body temperature. This suggests a lower density of brain opioid receptors in these animals.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Animal Behavior

    Background:

    • Pointer dogs with a genetic predisposition for nervousness exhibit distinct physiological responses.
    • Opioid receptors in the brain play a crucial role in regulating physiological functions.
    • Previous research suggests potential differences in opioid receptor density in nervous dogs.

    Purpose of the Study:

    • To investigate the differential effects of morphine and pentobarbital on body temperature and heart rate in genetically nervous pointer dogs compared to controls.
    • To explore the relationship between opioid receptor density and drug response in this canine model.

    Main Methods:

    • Intravenous administration of cumulative doses of morphine and pentobarbital to conscious, restrained nervous and control dogs.

    Related Experiment Videos

  • Monitoring of body temperature and heart rate as key physiological indicators.
  • Comparison of drug-induced physiological changes between nervous and control dog groups.

    • Main Results:

    • Morphine administration resulted in significantly less tachycardia and hypothermia in nervous dogs compared to control dogs.
    • Nervous and control dogs showed no significant differences in their physiological responses to pentobarbital.
    • These findings align with existing data indicating lower opioid receptor density in the brains of nervous dogs.

    Conclusions:

    • Genetically nervous dogs display an altered physiological response to morphine, likely due to reduced central opioid receptor density.
    • Pentobarbital's effects are not significantly different between nervous and control dogs, suggesting a specific role for opioid pathways in the observed differences.
    • This study reinforces the link between opioid receptor availability and drug-induced physiological effects in a genetically defined animal model.