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Related Experiment Videos

Changes in intercellular junctions. I. Embryonic chick liver development.

R A Meyer, J Overton

    Developmental Biology
    |September 1, 1983
    PubMed
    Summary
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    As chick embryo liver cells mature, their cell division rate decreases. This is linked to increasing tight junctions and changing gap junction patterns, impacting cell organization and function.

    Area of Science:

    • Hepatocyte development
    • Cell biology
    • Developmental biology

    Background:

    • Intercellular junctions are crucial for tissue development and function.
    • Understanding junctional changes during hepatocyte development can elucidate links to cell proliferation, morphogenesis, and differentiation.

    Purpose of the Study:

    • To quantify changes in intercellular junctions during chick embryo hepatocyte development.
    • To correlate these junctional changes with cell proliferation and tissue organization.

    Main Methods:

    • Thymidine labeling to assess cell proliferation rates at different embryonic and posthatching stages.
    • Analysis of tight and gap junction morphology and distribution using microscopy.
    • Scanning electron microscopy to observe cell reorganization.

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    Main Results:

    • A decline in thymidine labeling index (cell proliferation) correlated with an increase in tight junction coverage.
    • Tight junction morphology evolved from linear/macular to anastomosing and parallel strands.
    • Gap junction area increased by embryonic stage 28 and then decreased; ATPase activity appeared at stage 28.

    Conclusions:

    • Hepatocyte maturation involves significant changes in junctional patterns.
    • These junctional modifications are likely correlated with altered proliferative rates and synthetic activities during liver development.