The effect of androgens on DNA synthesis by fetal hemopoietic stromal cells

Fibroblast-like stromal cells from mid-term fetal bovine liver and bone marrow were grown in liquid culture. The low proliferative activity of these cells is highly increased by serum, after entering a quiescent stage by a serum step-down stimulus. In such condition, androgens stimulate DNA synthesis in stromal cells derived from liver. An inhibitory effect, however, was observed in stromal cells from fetal bone marrow.