Azlocillin kinetics during extracorporeal haemodialysis and peritoneal dialysis

The kinetic disposition of azlocillin in patients with end stage renal failure was evaluated in six individuals maintained on chronic extracorporeal haemodialysis and in six individuals on peritoneal dialysis. In the absence of renal function the plasma half-life of azlocillin was extended from the normal value of approximately 60 min to 235 +/- 30 min. During peritoneal dialysis the plasma half-life was reduced to 148 +/- 15 min and during extracorporeal haemodialysis it was further reduced to 112 +/- 11 min. Azlocillin was readily dialysed during haemodialysis but its removal rate during peritoneal dialysis was substantially less.