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Related Experiment Videos

Temocillin in peripheral lymph.

T Bergan, A Engeset, W Olszewski

    The Journal of Antimicrobial Chemotherapy
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Temocillin effectively penetrates peripheral lymph fluid, reaching significant concentrations after intravenous administration in healthy volunteers. This antibiotic demonstrates good distribution into extravascular tissues, with a serum half-life of 4.9 hours.

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    Area of Science:

    • Pharmacokinetics
    • Infectious Diseases
    • Clinical Pharmacology

    Background:

    • Temocillin is a beta-lactamase resistant penicillin antibiotic.
    • Understanding drug distribution into tissues is crucial for effective treatment of infections.
    • Extravascular penetration, particularly into lymph, influences therapeutic efficacy.

    Purpose of the Study:

    • To investigate the pharmacokinetic profile of temocillin in human serum and peripheral lymph.
    • To determine the extent of temocillin penetration into extravascular fluid compartments.
    • To assess the relationship between serum and lymph concentrations of temocillin.

    Main Methods:

    • Intravenous administration of 1 gram of temocillin to five healthy volunteers.
    • Collection of serum and peripheral lymph samples via lower leg cannulation.

    Related Experiment Videos

  • Quantification of temocillin concentrations using validated analytical methods.
  • Analysis of pharmacokinetic parameters including half-life and area under the concentration-time curve (AUC).

    • Main Results:

    • Peak lymph concentrations of temocillin reached 30.6 mg/l between 1.5-2 hours post-administration.
    • Lymph antibiotic levels were consistently lower than simultaneous serum levels, with a mean lymph/serum AUC ratio of 0.558.
    • The serum half-life was 4.9 hours, and the apparent distribution volume was 18.4 L, with a comparable lymph half-life of 4.4 hours.
    • Urinary recovery over 12 hours was approximately 60%.

    Conclusions:

    • Temocillin demonstrates significant penetration into peripheral lymph fluid in healthy volunteers.
    • The drug's distribution into extravascular spaces appears efficient, suggesting good potential for treating infections in these sites.
    • Protein binding is likely not a major limiting factor for temocillin's extravascular distribution.