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The intraperitoneal penetration of temocillin
The Journal of Antimicrobial Chemotherapy
|July 1, 1983
Summary
Temocillin demonstrates rapid intraperitoneal penetration after intravenous injection, reaching significant concentrations within the first hour. Dosing 1 gram twice daily is predicted to effectively inhibit susceptible pathogens in the peritoneal cavity.
Area of Science:
- Pharmacokinetics
- Surgical Infections
- Antibiotic Therapy
Background:
- Gastrointestinal surgery carries a risk of intraperitoneal infections.
- Optimizing antibiotic concentrations in the peritoneal fluid is crucial for effective treatment.
- Temocillin is a beta-lactam antibiotic with potential utility in surgical prophylaxis and treatment.
Purpose of the Study:
- To evaluate the intraperitoneal penetration of temocillin following intravenous administration.
- To determine the pharmacokinetic profile of temocillin in peritoneal fluid.
- To assess the potential efficacy of temocillin for treating intraperitoneal infections.
Main Methods:
- Intraperitoneal penetration study of temocillin.
- 1 gram intravenous injection administered to 28 patients.
- Measurement of temocillin serum and peritoneal fluid levels over 3.5 hours.
Main Results:
- Temocillin exhibited rapid penetration into the peritoneal cavity.
- Peritoneal fluid levels reached 48% of serum levels within the first hour.
- The mean peritoneal concentration of temocillin was 49.1 mg/l over 3.5 hours.
Conclusions:
- A 1 gram twice-daily intravenous dose of temocillin achieves high intraperitoneal concentrations.
- These concentrations are expected to be sufficient to inhibit susceptible bacterial pathogens.
- Temocillin shows promise as an effective therapeutic agent for intraperitoneal infections.