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Related Experiment Videos

Immune suppression induced by acetoacetylated antigen.

O Strannegård, L Lindholm

    International Archives of Allergy and Applied Immunology
    |January 1, 1977
    PubMed
    Summary

    Injecting a specific antigen into rabbits suppressed an ongoing immune response. Studies in mice showed that cells from primed animals could also suppress antibody production, suggesting a role for suppressor cells in immune regulation.

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    Area of Science:

    • Immunology
    • Cellular immunology

    Background:

    • Reagin-mediated immune responses are crucial in allergic reactions.
    • Antigen injection can modulate ongoing immune responses.

    Purpose of the Study:

    • To investigate the mechanism by which acetoacetylated antigen abrogates ongoing reagin responses.
    • To determine if suppressor cells are involved in this immune modulation.

    Main Methods:

    • Experimental autoimmune models in rabbits and mice.
    • Cell transfer experiments using thymus and spleen cells.
    • Measurement of IgG and IgM antibody responses.

    Main Results:

    • Acetoacetylated antigen injection abrogated ongoing reagin responses in rabbits.
    • Thymus or spleen cells from antigen-primed mice suppressed IgG and IgM antibody production upon transfer.
    • Maximal suppression was observed 12-14 days post-priming with both native and acetoacetylated antigens.
    • Both IgG and IgM responses were equally suppressed.

    Conclusions:

    • The abrogation of reagin responses by acetoacetylated antigen involves the activation of suppressor cells.
    • Immune tolerance can be induced via antigen-specific suppressor cell activation.

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