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Related Experiment Videos

Cyclobenzaprine overdosage.

C H Linden, J C Mitchiner, R D Lindzon

    Journal of Toxicology. Clinical Toxicology
    |May 1, 1983
    PubMed
    Summary

    Cyclobenzaprine (Flexeril) overdose causes prolonged anticholinergic symptoms, sometimes treatable with physostigmine. Unlike amitriptyline, it did not lead to severe toxicity like coma or seizures.

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    Area of Science:

    • Pharmacology
    • Clinical Toxicology

    Background:

    • Cyclobenzaprine, a muscle relaxant, shares structural similarities with tricyclic antidepressants.
    • Understanding the toxicological profile of cyclobenzaprine overdose is crucial for clinical management.

    Observation:

    • Three patients ingested significant amounts of cyclobenzaprine (260-900 mg).
    • Clinical presentation included delayed onset and prolonged anticholinergic symptoms.

    Findings:

    • Two patients responded to physostigmine treatment for anticholinergic toxicity.
    • One patient recovered without specific intervention.
    • No coma, seizures, or cardiac toxicity were observed, differentiating it from amitriptyline overdose.

    Implications:

    • The unique pharmacological properties of cyclobenzaprine may explain its distinct toxicity profile.
    • Physostigmine can be an effective treatment for cyclobenzaprine-induced anticholinergic toxicity.
    • This study highlights the importance of considering drug-specific effects in overdose cases.

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