Hemoperfusion with uncoated amberlite XE-336 resin in normal and uremic dogs

Amberlite XE-336 is a pyrolized polystyrene resin with an adsorptive spectrum similar to activated charcoal. 5 normal (group I) and 5 uremic (group II) dogs had 6 h of hemoperfusion with a 400-gram column of Amberlite XE-336 resin with a blood flow rate of 300 ml/min. In group II during 0, 0.5, 1, 3, and 6 h of hemoperfusion the mean column clearances of creatinine were 273 +/- 10, 224 +/- 7, 177 +/- 8, 125 +/- 30, and 64 +/- 17 ml/min and the serum creatinine concentration decreased from 10.4 +/- 1.3 to 3.2 +/- 0.9 mg/dl. In one of the uremic dogs the column clearance of middle molecules measured at 0, 0,5, 1, 3, and 6 h of hemoperfusion was 273,258,101,109, and 23 ml/min. The side reactions in group I and II hemoperfusion studies included transient hypotension, hypocalcemia, leukopenia and a reduction in platelet count.