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Genotoxicity of quinone pigments from pathogenic fungi
Abstract:
The genotoxicity and mutagenicity of several kinds of quinone pigments from pathogenic fungi were examined by means of the hepatocyte primary culture (HPC)/DNA repair test and of Ames test with TA98 and TA100. Clear genotoxicity of the two quinone chemicals, xanthomegnin and luteosporin were observed in the HPC/DNA repair test, though definite mutagenicity was not detected in the Salmonella microsome test. These two pigments are thus suspected to be genotoxic carcinogens.
Insights
Two fungal quinone pigments, xanthomegnin and luteosporin, showed genotoxicity in the hepatocyte primary culture/DNA repair test. Despite lacking mutagenicity in the Ames test, they are suspected genotoxic carcinogens.
Area of Science:
- Mycology
- Toxicology
- Genetics
Background:
- Pathogenic fungi produce quinone pigments with potential toxicological effects.
- Understanding the genotoxicity and mutagenicity of these fungal compounds is crucial for risk assessment.
Purpose of the Study:
- To evaluate the genotoxicity and mutagenicity of quinone pigments from pathogenic fungi.
- To assess the carcinogenic potential of xanthomegnin and luteosporin.
Main Methods:
- Hepatocyte primary culture (HPC)/DNA repair test was employed to assess genotoxicity.
- Ames test (using Salmonella typhimurium strains TA98 and TA100) was used to evaluate mutagenicity.
Main Results:
- Xanthomegnin and luteosporin demonstrated clear genotoxicity in the HPC/DNA repair test.
- Definitive mutagenicity was not detected for these two quinone chemicals in the Ames test.
Conclusions:
- Xanthomegnin and luteosporin exhibit genotoxic properties.
- These fungal pigments are suspected genotoxic carcinogens, warranting further investigation.