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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

[Cardiac cerebral embolism]

P Berlit

    Der Nervenarzt
    |August 1, 1983
    PubMed

    Insights

    Cardiogenic brain embolism, often from ischemic heart disease, presents suddenly with neurological symptoms. Early anticoagulant therapy may improve outcomes by preventing further clots.

    Area of Science:

    • Neurology
    • Cardiology
    • Radiology

    Context:

    • Cardiogenic brain embolism is a significant cause of stroke.
    • Understanding its origins, presentation, and outcomes is crucial for patient management.

    Purpose:

    • To analyze the symptoms, diagnosis, prognosis, and therapy of 135 cases of cardiogenic brain embolism.
    • To identify common cardiac sources and neurological manifestations.

    Summary:

    • Ischemic heart disease with atrial fibrillation was the most frequent cause, followed by valvular heart disease, myocardial infarction, and carditis.
    • Sudden onset of neurological symptoms, often in the morning, characterized presentations. Initial loss of consciousness and seizures were poor prognostic indicators.
    • Angiographic findings included occlusions in the internal carotid artery and middle cerebral artery branches. Computed tomography (CT) and lumbar puncture were not diagnostic.

    Impact:

    • Mortality was 22%, with 34% experiencing significant neurological deficits, highlighting the serious prognosis.
    • Recommended cardiologic evaluations include chest X-ray, long-term electrocardiogram, and echocardiography.
    • Early anticoagulant therapy, if no cerebral hemorrhage is present on CT, may prevent re-embolization and improve outcomes.

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