Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Memory functions and prophylactic treatment with lithium.

L Smigan, C Perris

    Psychological Medicine
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Developing practice in cancer rehabilitation.

    European journal of cancer care·2009
    Same author

    Assessment of dysfunctional working models of self and others in schizophrenic patients: a summary of data collected in nine nations. International Research Group.

    Acta psychiatrica Scandinavica·2000
    Same author

    Transhistorical variations in personality and their association with experiences of parental rearing.

    European psychiatry : the journal of the Association of European Psychiatrists·1999
    Same author

    Parental influences do matter!

    Acta psychiatrica Scandinavica·1999
    Same author

    Development and preliminary application of a new scale for assessing dysfunctional working models of self and others (DWM-S) in severely disturbed patients.

    Acta psychiatrica Scandinavica·1998
    Same author

    Perceived parental rearing behaviour in patients with a schizophrenic disorder and its relationship to aspects of the course of the illness.

    Acta psychiatrica Scandinavica·1996
    Same journal

    Distinct and common subcortical functional connectivity revealed across three major psychiatric disorders - CORRIGENDUM.

    Psychological medicine·2026
    Same journal

    Adversity as the key feature: neuroimaging profiles of subtypes from multiple depression risk factors.

    Psychological medicine·2026
    Same journal

    Sorting the mind: cognitive enhancement through transcutaneous auricular vagus nerve stimulation: a systematic review and meta-analysis.

    Psychological medicine·2026
    Same journal

    Depression and aging: insights from brain age prediction models.

    Psychological medicine·2026
    Same journal

    An integrative NLP framework identifies multilevel linguistic phenotypes of schizophrenia across tasks.

    Psychological medicine·2026
    Same journal

    Predicting functional remission after antipsychotic discontinuation: a real-world study in schizophrenia - ERRATUM.

    Psychological medicine·2026
    See all related articles

    Long-term lithium treatment for affective disorders did not impair memory functions. Cognitive assessments showed no significant memory decline after 4 and 12 months of therapy.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Affective disorders are often treated with mood stabilizers like lithium.
    • Concerns exist regarding potential cognitive side effects of long-term lithium therapy.

    Purpose of the Study:

    • To investigate the impact of prophylactic lithium treatment on memory functions in patients with affective disorders.
    • To assess memory performance at baseline and after 4 and 12 months of lithium therapy.

    Main Methods:

    • A cohort of 53 patients with affective disorders underwent memory testing before and during lithium treatment.
    • Memory was evaluated using the Cronholm-Molander test battery, including the 30 Figure Test, 30 Word-Pair Test, 30 Person-Data Test, and 30 Face Test.
    • Immediate memory, delayed memory, and forgetting scores were analyzed.

    Related Experiment Videos

    Main Results:

    • No statistically significant differences in overall memory scores were observed before and after lithium treatment.
    • A notable improvement in immediate and delayed memory was found for the Person-Data Test and 30 Face Test.
    • Long-term lithium treatment at serum levels around 0.6 mmol/l did not negatively affect memory.

    Conclusions:

    • Prophylactic lithium therapy for affective disorders does not appear to induce memory disturbances.
    • The findings suggest lithium's safety profile regarding cognitive function in this patient population.
    • Further research could explore the specific mechanisms behind the observed memory improvements in certain tests.