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[The spine and polytopic hyperostoses in gout and hyperuricemia].

J Stĕpán, V Sváb, J Kolár

    Der Radiologe
    |August 1, 1983
    PubMed
    Summary

    Gout patients often show spinal changes like vertebral erosion and joint issues. Hyperostosis and calcifications in gout may link to latent carbohydrate metabolism disorders.

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    Area of Science:

    • Rheumatology
    • Orthopedics
    • Metabolic Diseases

    Background:

    • Gout and hyperuricemia are associated with various clinical manifestations.
    • Spinal involvement in gout is not always clinically apparent.
    • Hyperuricemia can lead to systemic complications beyond joint inflammation.

    Purpose of the Study:

    • To investigate the prevalence and nature of spinal and extraspinal manifestations in patients with gout and hyperuricemia.
    • To explore potential correlations between hyperostotic changes in gout and latent metabolic disorders.

    Main Methods:

    • Radiological and xero-radiographic examinations were performed on 70% of the 92 patients.
    • Clinical signs of spinal involvement were assessed.
    • Prevalence of polytopic hyperostoses, calcifications, and periosteal appositions was recorded.

    Main Results:

    • 70% of patients exhibited radiological signs of spinal involvement, including vertebral erosion, spondylodiscitis, osteopenia, Forestier's disease, and sacroiliac joint changes.
    • 35% of subjects presented with polytopic hyperostoses, characterized by increased calcifications around large joints and periosteal appositions.
    • Specific findings included peripheral periosteal appositions on finger and toe tips.

    Conclusions:

    • Gout and hyperuricemia are associated with significant radiological findings in the spine and joints.
    • The observed massive calcifications and hyperostosis in gout patients suggest a potential link to latent carbohydrate metabolism disorders, similar to Forestier's disease.
    • Further research is warranted to elucidate the relationship between gout, hyperostosis, and metabolic disturbances.

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