Work in progress: transcatheter embolization with cyanoacrylate and nitrocellulose

Area of Science:

• Biomedical Engineering
• Interventional Radiology
• Vascular Surgery

Background:

• Transcatheter embolization is a minimally invasive procedure used to block blood vessels.
• Traditional embolic agents may have limitations in delivery and polymerization control.
• Isobutyl-2-cyanoacrylate (IBCA) is a commonly used embolic agent.

Purpose of the Study:

• To describe a modified isobutyl-2-cyanoacrylate (IBCA) formulation with enhanced properties for transcatheter embolization.
• To evaluate the safety and efficacy of this modified IBCA in animal models.
• To assess the delivery characteristics and polymerization behavior of the modified agent.

Main Methods:

• A modified IBCA formulation was created by mixing it with less than or equal to 4% w/w of nitrocellulose.
• Transcatheter embolization procedures were performed in rabbits and dogs using the modified IBCA.
• The injectability, delivery into peripheral arterial branches, and polymerization characteristics were observed.

Main Results:

• The modified IBCA was readily injectable without the need for balloon catheters.
• Delayed polymerization allowed the agent to be carried into smaller arterial branches by blood flow.
• Complete organ ablation was achieved without the development of collateral circulation.
• The modified compound demonstrated improved plasticity and adherence to various surfaces.
• The duration of polymerization could be controlled.

Conclusions:

• The modified IBCA with nitrocellulose offers a safe and effective embolic agent for transcatheter embolization.
• Its controlled polymerization and delivery characteristics facilitate precise embolization and complete organ ablation.
• This enhanced formulation presents advantages over traditional agents, including improved handling and broader applicability.