Influence of amphetamine on brown adipose thermogenesis

Amphetamine (0.5, 1.0, 2.0 or 4.0 mg/kg) produced dose-dependent activation of interscapular brown-adipose tissue (IBAT) in female rats anesthetized with urethane (1.2 g/kg). Amphetamine-induced thermogenesis may reflect activation of beta-adrenergic receptors as evidenced by the rapid reversal of amphetamine-induced thermogenesis by propranolol (1.0 mg/kg). The potential relation of this effect to the anorexic property of amphetamine is discussed.