Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Amrinone-mediated thrombocytopenia.

E L Kinney, J O Ballard, B Carlin

Scandinavian Journal of Haematology

|October 1, 1983

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of a variable-energy, high-intensity, pulsed-mode ion source for low-energy nuclear astrophysics studies.

The Review of scientific instruments·2018

Same author

Characterisation of the interactive properties of microcrystalline cellulose-carboxymethyl cellulose hydrogels.

International journal of pharmaceutics·2011

Same author

A piece of my mind. To bed with Dad.

JAMA·2010

Same author

Fibrinogen interaction with human platelets: effect of other coagulation factors, prostaglandins and platelet inhibitors.

Thrombosis research·2010

Same author

A piece of my mind. More things in heaven and earth.

JAMA·2009

Same author

A piece of my mind. Provenance.

JAMA·2009

Same journal

Role of iron in the proliferation of the established human tumor cell lines U-937 and K-562: effects of suramin and a lipophilic iron chelator (PIH).

Scandinavian journal of haematology·1986

Same journal

The efficacy and toxicity of VAD in the treatment of myeloma and related disorders.

Scandinavian journal of haematology·1986

Same journal

RES phagocytosis in children with homozygous beta-thalassemia in relation to blood transfusion.

Scandinavian journal of haematology·1986

Same journal

Two allotypes of factor IX present in haemophilia B.

Scandinavian journal of haematology·1986

Same journal

Radioimmunoassay of erythropoietin in chronic uraemia or anephric patients.

Scandinavian journal of haematology·1986

Same journal

Prognostic significance of a morphometric study of lymph node biopsies in chronic lymphocytic leukaemia.

Scandinavian journal of haematology·1986

See all related articles

Amrinone treatment for severe heart failure led to low platelet counts in several patients. Further research is needed to understand why this common side effect occurs.

Area of Science:

Cardiology
Pharmacology
Hematology

Background:

Severe congestive heart failure (CHF) presents significant therapeutic challenges.
Existing treatments for advanced CHF have limitations.
Novel cardioactive agents are under investigation.

Purpose of the Study:

To evaluate the safety and efficacy of amrinone in patients with severe congestive heart failure.
To identify potential adverse effects associated with amrinone administration.

Main Methods:

A cohort of 12 patients with severe CHF received amrinone.
Treatment duration averaged 27.9 days.
Platelet counts were monitored throughout the study period.

Main Results:

Related Experiment Videos

Thrombocytopenia (low platelet count) was observed in 4 patients.
A progressive decline in platelet numbers occurred in an additional 3 patients.
Adverse hematological effects were noted in a significant proportion of the study group.

Conclusions:

Amrinone administration in severe CHF patients is associated with a notable incidence of thrombocytopenia.
The mechanism underlying amrinone-induced platelet reduction requires further investigation.
The frequency of these adverse effects warrants careful consideration during clinical use.