Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extrapulmonary lesions in influenza.

A V Zinserling, O A Aksenov, V F Melnikova

    The Tohoku Journal of Experimental Medicine
    |July 1, 1983
    PubMed
    Summary

    Influenza can spread from the respiratory system to other organs in children, including the brain. This study found influenza virus antigens in multiple organs and confirmed viral generalization in mice, revealing key aspects of disease pathogenesis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Clinical, laboratory and morphological comparisons in cellular alteration under conditions of hypoxia].

    Arkhiv patologii·2024
    Same author

    [Pathogenesis and pathological anatomy of chlamydial infections].

    Arkhiv patologii·2024
    Same author

    [Pathological profile of S.P. Botkin infectious hospital during the siege of Leningrad (1941-1944)].

    Arkhiv patologii·2024
    Same author

    [Analysis of fatal outcomes of meningococcal infection in adults].

    Terapevticheskii arkhiv·2023
    Same author

    [Vsevolod Dmitrievich Zinserling. (On the occasion of the 130th anniversary of his birth)].

    Arkhiv patologii·2021
    Same author

    [Pathological anatomy of tuberculosis in the presence of human immunodeficiency virus infection].

    Arkhiv patologii·2020

    Area of Science:

    • Pediatric Pathology
    • Virology
    • Immunohistochemistry

    Background:

    • Influenza is a common respiratory illness in children.
    • The potential for systemic viral dissemination in influenza is not fully understood.

    Purpose of the Study:

    • To investigate the possibility of hematogenic influenza virus dissemination from the respiratory system in children.
    • To explore the pathogenesis of influenza, including viral spread to various organs and associated cellular changes.

    Main Methods:

    • Autopsy analysis of 270 pediatric influenza cases.
    • Histological, immunofluorescent, serological, and virological examination of 180 newborn mice.
    • Electron microscopy for viral particle identification.

    Main Results:

    • Influenza antigen was detected in the liver, intestine, kidneys, and brain of children with influenza.
    • Viral particles were observed in chronic inflammatory brain lesions via electron microscopy.
    • Experimental studies confirmed influenza generalization in mice, with specific structural changes noted in affected organs.

    Conclusions:

    • Influenza virus can disseminate hematogenously from the respiratory tract to multiple organs in children.
    • The study provides evidence for systemic influenza infection and discusses its pathogenesis.
    • Findings highlight the importance of considering systemic influenza involvement in pediatric cases, particularly neurological complications.

    Related Experiment Videos