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Subacute toxicity of Basalin in rats
Toxicology Letters
|August 1, 1983
Summary
Basalin herbicide caused toxicity in male rats, including hyperexcitability and tremors. Cumulative toxicity led to a lethal dose of 135 mg/kg, impacting blood counts and liver function.
Area of Science:
- Toxicology
- Environmental Science
Background:
- Basalin is a herbicide used in agriculture.
- Understanding herbicide toxicity is crucial for environmental and human health risk assessment.
Purpose of the Study:
- To evaluate the oral toxicity of Basalin in male rats over a 13-week period.
- To determine the lethal dose and observe toxicological effects.
Main Methods:
- Male rats were administered oral doses of Basalin ranging from 60 mg to 1.92 g/kg for 13 weeks.
- Evaluated toxic effects, mortality, body weight gain, total leukocyte count (TLC), erythrocyte sedimentation rate (ESR), hemoglobin (Hb), spermatogenesis, and liver histology.
Main Results:
- The oral LD50 was determined to be 1.65 g/kg.
- Cumulative lethal dose (CLD50) was 135 mg/kg with a cumulative toxicity factor (CTF) of 12.22.
- Observed hyperexcitability, tremors, decreased TLC, ESR, Hb, impaired spermatogenesis, and liver cell infiltration.
Conclusions:
- Basalin exhibits significant oral toxicity in male rats.
- Chronic exposure can lead to hematological changes, reproductive toxicity, and liver damage.