Behaviour of lysosomal enzymes in the small intestine after multiple daily fractionation

Modifications in the activities of some lysosomal enzymes were studied in the small intestine after irradiation on the abdomen by multiple daily fractionation of 3 Gy per fraction every 12 hours. Total doses of 6 and 12 Gy were studied. With lower dose variations were slight. The modifications of acid phosphatase an cathepsin D appeared very low, whereas beta-glucuronidase increased until 72 hours after the last fraction and then returned to control values. With respect to 8 Gy single dose the injury appeared comparatively similar.