[Cerebrocortical necrosis in calves, sheep and goats]

Cerebrocortical necrosis was induced through the oral application of amprolium to calves (0.250 g/kg to 1.00 g/kg) and weaned lambs and goats (1.25 g/kg) in the course of 25 to 35 days. In order to shed light on the etiology of the disease an experiment was carried out with a ration rich in carbohydrates for calves and sheep. Clinically, the disease was manifested with nervous symptoms. Biochemically, a drop of the amount of B1 in the blood serum, liver, and brain was established, along with a rise of pyruvic acid in the blood serum. Morphologically, most characteristic were the laminar necroses, the domination colliquative processes that led to deformation, and the atrophy of the folds of the brain cortex. Analogous changes were found also in the investigation of the spontaneously affected calves and lambs originating from different farms.