The central corneal thickness in patients with Horner's syndrome

In 14 patients with unilateral Horner's syndrome there was a significant increase in central corneal thickness on the affected side (mean difference 4.86 micron +/- SEM 1.71 micron; P less than 0.02). It is suggested that the sympathetic nerve supply of the eye is of importance for corneal hydration. Different possible mechanisms are discussed. Among the investigated patients no permanent ocular hypotonia or hyperaemia was found. On slit-lamp investigation there was no corneal change. The corneal sensitivity was equal on both sides.