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Amiodarone induced cornea verticillata.

C E Nielsen, F Andreasen, P Bjerregaard

    Acta Ophthalmologica
    |June 1, 1983
    PubMed
    Summary

    Amiodarone, an antiarrhythmic drug, can cause cornea verticillata in patients. Tear amiodarone levels increase with serum concentrations, correlating with treatment duration and dosage.

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    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Cardiology

    Background:

    • Amiodarone is a widely used antiarrhythmic medication.
    • Ocular side effects, including cornea verticillata, are known complications of amiodarone therapy.
    • Understanding the relationship between amiodarone levels and ocular manifestations is crucial for patient management.

    Purpose of the Study:

    • To investigate the incidence of cornea verticillata in patients treated with amiodarone.
    • To determine the correlation between serum and tear amiodarone concentrations and the development of cornea verticillata.
    • To assess other potential ocular side effects associated with amiodarone treatment.

    Main Methods:

    • Retrospective analysis of 30 patients receiving amiodarone.
    • Ophthalmic examination to assess for cornea verticillata.
    • Measurement of amiodarone concentrations in tear fluid and serum samples.
    • Statistical analysis to correlate drug levels, treatment parameters, and clinical findings.

    Main Results:

    • 21 out of 30 patients developed bilateral cornea verticillata.
    • Tear amiodarone concentrations significantly increased at serum levels above 1.2 µg/ml.
    • The severity of cornea verticillata correlated significantly with total amiodarone dose and treatment duration.
    • No significant correlation was found between current serum/tear amiodarone levels and the grade of cornea verticillata on the examination day.
    • No other significant ocular adverse effects were reported.

    Conclusions:

    • Cornea verticillata is a common finding in patients on long-term amiodarone therapy.
    • Tear amiodarone levels serve as a potential indicator of systemic drug exposure.
    • While dose and duration are key factors, current drug levels may not directly reflect the grade of established cornea verticillata.

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