Early recognition of the patient at late high risk: incomplete infarction and vulnerable myocardium

The process of identifying patients with myocardial infarction (MI) at high risk after hospital discharge should begin at admission. By using basic clinical and laboratory information, enhanced by a wide variety of noninvasive tests, not only can individual patients at risk be recognized, but also the processes that determine risk can, at least in part, be appreciated. Outcome is affected by the extent of damaged tissue and, apparently, by the amount of potentially ischemic muscle. MI may change the coronary circulation such that a new and fragile balance between supply and demand results, both within and outside the infarct zone; that is, the infarct may be incomplete and the viable muscle within it may then be vulnerable to later ischemia. Muscle outside the infarct zone may be left in much the same precarious state. Also, coronary spasm may not be infrequent in the weeks after MI. These factors together may underlie recurrent post-MI myocardial ischemia.