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Decrease of lipase and esterase activities in intestinal contents of newborn infants during test meals.

B Fredrikzon, T Olivecrona

    Pediatric Research
    |May 1, 1978
    PubMed
    Summary

    Newborns have lower lipase and esterase activity in their intestines compared to adults. This may contribute to less efficient infant lipid absorption, suggesting a reliance on other lipase sources.

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    Area of Science:

    • Gastroenterology
    • Pediatric Nutrition
    • Digestive Physiology

    Background:

    • Lipase and esterase activities are crucial for lipid digestion.
    • Understanding enzyme activity in newborns is vital for assessing digestive function.
    • Infant lipid absorption is often less efficient than in adults.

    Purpose of the Study:

    • To compare intestinal lipase and esterase activities between newborns and adults.
    • To investigate the impact of feeding on these enzyme activities in infants.
    • To explore potential reasons for reduced lipid absorption in newborns.

    Main Methods:

    • Analysis of intestinal contents from newborns and adults.
    • Measurement of lipase and esterase activities following a test meal.

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  • Comparison of enzyme activity levels between the two age groups.

    • Main Results:

    • Lipase and esterase activities were detected in all newborns from day one.
    • In adults, lipase activity increased post-meal, while esterase remained stable.
    • Infant enzyme activities decreased post-meal and were significantly lower than in adults.

    Conclusions:

    • Newborns exhibit considerably lower intestinal lipase and esterase activity than adults.
    • Incomplete pancreatic function in newborns may lead to reduced lipolytic enzyme output.
    • Newborns might depend more on alternative lipase sources, like human milk lipase.