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Analytical biases with liquid quality control material.

P J Howanitz, J H Howanitz, H V Lamberson

    American Journal of Clinical Pathology
    |October 1, 1983
    PubMed
    Summary
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    This study compared biases in clinical chemistry analytes using liquid and lyophilized control materials. Liquid control materials generally showed greater biases, but large pool sizes minimize consequences for interlaboratory precision.

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Analytical Chemistry

    Background:

    • Interlaboratory comparisons are crucial for assessing analytical performance.
    • Control materials, both liquid and lyophilized, are used in quality control programs.
    • Understanding biases in these materials is essential for accurate diagnostic testing.

    Purpose of the Study:

    • To compare analytical biases for eight common chemistry analytes using liquid versus lyophilized control materials.
    • To evaluate the impact of analyte concentration on observed biases.
    • To assess the utility of liquid control materials for monitoring interlaboratory precision.

    Main Methods:

    • Data from over 350 laboratories in a quality control program were analyzed.
    • Biases were determined for eight analytes using common chemistry instruments.

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  • Results from liquid control sera were compared with data from lyophilized materials and a CAP proficiency survey.

    • Main Results:

    • Biases generally increased proportionally with analyte concentration.
    • Most analytes exhibited greater biases with liquid control materials compared to lyophilized materials.
    • For a few analytes, biases were less pronounced with liquid materials.

    Conclusions:

    • Liquid control materials can exhibit greater analytical biases than lyophilized materials, particularly at higher analyte levels.
    • Despite potential biases, the use of liquid materials in large-scale quality control programs effectively minimizes the impact on interlaboratory precision.
    • Careful selection and monitoring of control materials are necessary for reliable clinical laboratory testing.