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Cellular responses in human strongyloidiasis.

R M Genta, E A Ottesen, F A Neva

    The American Journal of Tropical Medicine and Hygiene
    |September 1, 1983
    PubMed
    Summary
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    Chronic strongyloidiasis patients show depressed T cell activity and serum factors that inhibit parasite-specific immune responses in vitro. This impacts their cellular immunity against the Strongyloides stercoralis parasite.

    Area of Science:

    • Immunology
    • Parasitology
    • Cellular Biology

    Background:

    • Strongyloidiasis is a parasitic infection caused by Strongyloides stercoralis.
    • Chronic strongyloidiasis can lead to altered immune responses.
    • Understanding these immune alterations is crucial for managing the infection.

    Purpose of the Study:

    • To investigate the in vitro immune responses of patients with chronic strongyloidiasis.
    • To assess the role of patient serum and plasma in modulating cellular immunity.
    • To identify potential inhibitory factors affecting immune responses to parasite antigens.

    Main Methods:

    • Peripheral lymphocytes from patients and controls were stimulated with Strongyloides antigens, other antigens, and phytohemagglutinin (PHA).
    • Cellular responses were measured in the presence of autologous plasma and normal human serum.

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  • Lymphoproliferative assays were used to quantify immune cell activity.

    • Main Results:

    • Patient lymphocyte responses to Strongyloides antigens were similar to controls in autologous plasma.
    • Normal human serum enhanced parasite-specific responses in patients' lymphocytes.
    • T cell responses to PHA were significantly lower in patients, indicating depressed T cell activity.
    • Patient serum contained factors that inhibited parasite-specific cellular responses in vitro.

    Conclusions:

    • Chronic strongyloidiasis is associated with suppressed T cell activity.
    • Serum factors in patients inhibit parasite-specific immune responses.
    • These findings highlight complex immune dysregulation in chronic strongyloidiasis.