Moxalactam concentrations in human prostatic tissue.

Area of Science:

• Pharmacology
• Urology
• Infectious Diseases

Background:

• Bacterial prostatitis is a common condition requiring effective antibiotic treatment.
• Understanding antibiotic penetration into prostatic tissue is crucial for optimizing therapy.
• Moxalactam is a beta-lactam antibiotic with activity against gram-negative bacteria.

Purpose of the Study:

• To quantify moxalactam concentrations in human prostatic tissue.
• To compare moxalactam levels in tissue obtained via different surgical methods.
• To assess the adequacy of moxalactam concentrations for treating common gram-negative pathogens.

Main Methods:

• Ten patients received two 500-mg intramuscular doses of moxalactam.
• Prostatic tissue samples were obtained via enucleation or transurethral resection.
• Moxalactam concentrations in tissue and plasma were measured using validated assays.

Main Results:

• Average moxalactam concentrations in prostatic tissue were 4.0 µg/g (enucleation) and 5.2 µg/ml (transurethral resection).
• Prostate-to-plasma concentration ratios were 0.24 and 0.31, respectively.
• Achieved tissue concentrations surpassed minimum inhibitory concentrations for most common gram-negative pathogens.

Conclusions:

• Intramuscular moxalactam achieves therapeutic concentrations in human prostatic tissue.
• Tissue moxalactam levels are comparable between enucleated and transurethral resection specimens.
• Moxalactam demonstrates potential efficacy against gram-negative bacterial prostatitis.