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Moxalactam concentrations in human prostatic tissue.

R P Smith, H Wilbur, N T Sutphen

    Antimicrobial Agents and Chemotherapy
    |July 1, 1983
    PubMed
    Summary
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    Moxalactam concentrations in human prostate tissue after intramuscular injection exceeded minimum inhibitory levels for common gram-negative pathogens. Tissue levels were comparable between enucleation and transurethral resection specimens, indicating effective drug delivery.

    Area of Science:

    • Pharmacology
    • Urology
    • Infectious Diseases

    Background:

    • Bacterial prostatitis is a common condition requiring effective antibiotic treatment.
    • Understanding antibiotic penetration into prostatic tissue is crucial for optimizing therapy.
    • Moxalactam is a beta-lactam antibiotic with activity against gram-negative bacteria.

    Purpose of the Study:

    • To quantify moxalactam concentrations in human prostatic tissue.
    • To compare moxalactam levels in tissue obtained via different surgical methods.
    • To assess the adequacy of moxalactam concentrations for treating common gram-negative pathogens.

    Main Methods:

    • Ten patients received two 500-mg intramuscular doses of moxalactam.
    • Prostatic tissue samples were obtained via enucleation or transurethral resection.

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  • Moxalactam concentrations in tissue and plasma were measured using validated assays.

    • Main Results:

    • Average moxalactam concentrations in prostatic tissue were 4.0 µg/g (enucleation) and 5.2 µg/ml (transurethral resection).
    • Prostate-to-plasma concentration ratios were 0.24 and 0.31, respectively.
    • Achieved tissue concentrations surpassed minimum inhibitory concentrations for most common gram-negative pathogens.

    Conclusions:

    • Intramuscular moxalactam achieves therapeutic concentrations in human prostatic tissue.
    • Tissue moxalactam levels are comparable between enucleated and transurethral resection specimens.
    • Moxalactam demonstrates potential efficacy against gram-negative bacterial prostatitis.