"De-satiation": the reinstatement of feeding in glucose-satiated rats

In rats "satiated" for glucose in solution, feeding can be reinstated by presentation of the same commodity (glucose) in powdered form. The effect is not reciprocal, so it is not a response to change or variety per se; and it does not reflect a greater palatability of the powder, which is rejected in favor of the solution in choice tests. Sucrose powder leads to an even larger "second meal" than glucose powder, showing that intake in the solution-sated rat remains sensitive to the stimulus properties of the diet. We conclude that the postingestive conditions necessary for satiety must be set by the stimulus properties of the diet--including, but not limited to, the properties that specify a diet's nutrient composition.