[Enhancement of in vitro lymphocyte proliferative response by vitamin B compounds]

The effects of Vitamin B compounds consisting of B1, B6 and B12 on the in vitro lymphocyte proliferative (LP) response were investigated. Vitamin B compounds failed to enhance the LP response of healthy controls but did enhance that of cancer patients, suggesting the recovery of depressed LP response to normal level by the treatment employing the compounds. The addition of Vitamin B compounds in the generation phase of Concanavalin-A induced suppressor cells significantly abrogated the activities. However, Vitamin B compounds produced no effect to neutralize the inhibitory effect of cancer sera on LP response.