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Related Experiment Videos

Respiratory problems 2 years after acute bronchiolitis in infancy.

R L Henry, I G Hodges, A D Milner

    Archives of Disease in Childhood
    |September 1, 1983
    PubMed
    Summary

    Many children experience persistent respiratory symptoms and variable airway obstruction for years after acute bronchiolitis. Lung function tests reveal significant hyperinflation and reversible airway issues in a substantial portion of these young patients.

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    Area of Science:

    • Pediatric Pulmonology
    • Respiratory Medicine
    • Clinical Pediatrics

    Background:

    • Acute bronchiolitis is a common childhood respiratory infection.
    • Long-term respiratory sequelae after bronchiolitis are not fully understood.

    Purpose of the Study:

    • To evaluate the clinical progress and lung function in children 2 years post-hospitalization for acute bronchiolitis.
    • To identify factors associated with persistent respiratory symptoms and airway obstruction.

    Main Methods:

    • Prospective follow-up of 55 children admitted with acute bronchiolitis.
    • Lung function tests, including assessment of hyperinflation and airway reversibility to salbutamol, performed on 40 children at 2 years.
    • Clinical assessment of respiratory symptoms and hospital readmissions.

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    Main Results:

    • 75% of children experienced wheezing, and 36% had recurrent lower respiratory symptoms within 2 years.
    • 60% showed hyperinflation on lung function tests, with evidence of variable airway obstruction.
    • Nine children demonstrated reversible airway obstruction after salbutamol, correlating with higher baseline airway resistance.
    • Higher airway resistance was observed in children with a family history of atopy.

    Conclusions:

    • Children hospitalized for acute bronchiolitis frequently experience persistent respiratory symptoms and abnormal lung function, including hyperinflation and variable airway obstruction, for up to two years.
    • Airway hyperresponsiveness to bronchodilators may occur in a subset of these children.
    • Family history of atopy may be associated with increased airway resistance post-bronchiolitis.