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Arthritis and angioimmunoblastic lymphadenopathy
Annals of the Rheumatic Diseases
|October 1, 1983
Summary
Two cases of seronegative polyarthritis linked to angioimmunoblastic lymphadenopathy (AILD) are presented. One case showed concurrent onset, while the other developed polyarthritis before AILD, potentially due to azathioprine treatment.
Area of Science:
- Rheumatology
- Hematology
- Immunology
Background:
- Angioimmunoblastic lymphadenopathy (AILD) is a rare T-cell lymphoma.
- Seronegative polyarthritis can be a challenging diagnosis, especially when associated with systemic conditions.
Observation:
- Two distinct cases of seronegative polyarthritis associated with AILD were observed.
- Both patients presented with nonerosive, symmetrical arthritis affecting major joints like elbows, wrists, knees, and ankles.
Findings:
- In one case, arthritis manifested concurrently with systemic AILD symptoms.
- The second case experienced polyarthritis 18 months prior to AILD diagnosis, raising suspicion for azathioprine as a potential trigger.
Implications:
- These cases highlight the varied clinical presentations of arthritis in AILD.
- The potential role of azathioprine in AILD-associated polyarthritis warrants further investigation.